Author's response to reviews Title: Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations Authors:

Author's response to reviews Title: Genome-wide association studies reveal that the set of disease-associated alleles is enriched for derived low frequency alleles relative to HapMap and neutral expectations Authors:

Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province

Objective(s): HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases.  Among the genes are involved in HTLV-I infection, the role of human leukocytes antigen (HLA) have been studied in different population. In the pre...

Author's response to reviews Title: Non-Replication Study of a Genome-Wide Association Study for Hypertension and Blood Pressure in African Americans Authors:

Major compulsory revisions requested by reviewer: 1. The authors are attempting to replicate a genetic association study. However, the association analysis presented was not a genetic analysis but an epidemiologic analysis based on comparing genotype frequencies and ANOVA between the genotypes. A genetic association analysis (i.e. one that considers genetic models additive, recessive, dominant)...

Power to Detect Risk Alleles Using Genome-Wide Tag SNP Panels

Advances in high-throughput genotyping and the International HapMap Project have enabled association studies at the whole-genome level. We have constructed whole-genome genotyping panels of over 550,000 (HumanHap550) and 650,000 (HumanHap650Y) SNP loci by choosing tag SNPs from all populations genotyped by the International HapMap Project. These panels also contain additional SNP content in reg...

The Pattern of Linkage Disequilibrium in Livestock Genome

Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...